The Dutch College of General Practitioners (NHG) Practice Guideline

This NHG Practice Guideline is a translation of the Dutch guideline. It is specifically written for Dutch general practitioners in the Dutch enviroment. The advice which is given may therefore not be in accordence with the views of general practitioners in other countries.


NHG Practice Guideline 'Ankle sprains'     (January 2000)

A.N. Goudswaard, S. Thomas, W.J.H.M. van den Bosch, H.C.P.M. van Weert, R.M.M. Geijer
The guideline and its scientific basis have been updated with respect to the previous version (Huisarts Wet 1989;32:182-5). The recommendations remain essentially unchanged but some have been formulated more clearly and with better scientific justification. This applies especially to the value of the physical examination in detecting a fracture or ruptured ligament. The examination gives the general practitioner a better basis for determining which patients are eligible for an x-ray and also which should be treated with a tape bandage. Since the latter represent only 10 to 20% of patients with an inversion injury, the examination can prevent the overtreatment of patients with mild sprains.

 

INTRODUCTION

The NHG Practice Guideline 'Ankle sprains' provides guidance for the diagnosis and treatment of damage to the lateral ankle ligaments caused by an inversion injury.1 In this type of injury, the capsular ligaments on the lateral side of the ankle joint are strained. Depending on the force applied, the damage can range from a slight sprain to a rupture of one or more parts of the ligaments. This can be accompanied by a fracture in one of the bones of the ankle joint. This practice guideline lists the symptoms for which the general practitioner should consider the possibility of a fracture and should order an x-ray. The diagnostic process is also designed to distinguish between a mild sprain and a ligament rupture.2 This distinction is important because a mild sprain does not necessitate specific treatment, whereas functional treatment with a tape bandage is preferred for a rupture. By applying the guidelines in this standard, the general practitioner will be able to independently treat most patients with an inversion injury.

 

Background

Acute injury of the ankle is the most common form of injury involving the motor apparatus. Each year in The Netherlands, an estimated 300,000 patients visit the general practitioner or the hospital casualty department following an acute ankle injury. At least half of these injuries take place on playing fields. The incidence of inversion injuries in general practice is 12 per 1,000 patients per year.3

The probability of a fracture varies from about 5% in patients going to the general practitioner to 20% in those visiting the hospital casualty department. Fractures usually occur in the lateral malleolus or the fifth metatarsal bone, and sometimes in the medial malleolus or navicular bone. Some of these fractures do not require specific fracture treatment.4 The low probability of a fracture means that selective use of x-ray diagnostic equipment is important. It is possible to reduce the number of x-ray examinations by performing a simple clinical examination, without the risk that fractures will be missed.5

Studies carried out in Dutch casualty departments found the incidence of ligament ruptures in sprained ankles to be between 10 and 20%.6 The exact incidence of ruptures in patients who first visit the general practitioner is not known, but presumably it is close to the lower end of this range. The anterior talofibular ligament is nearly always involved in a rupture, sometimes together with one of the other ligaments.7 However, it is not necessary to determine whether more than one ligament has been ruptured, for that will not affect the prognosis or management.8

A physical examination immediately after or during the first days following the injury usually cannot distinguish between a rupture and a mild sprain. This is because pain, swelling, and muscle tension hamper the interpretation of the physical examination. Furthermore, during the acute phase both swelling and pain have a limited positive predictive value in terms of serious injury. Repeating the physical examination a few days later, when the pain and swelling have subsided through rest, is more useful in ascertaining the presence of a rupture.9 The treatment of ruptured ankle ligaments has been discussed often during recent decades. Appropriate comparative research has now shown that treatment with a tape bandage is as effective as surgery or immobilization by a plaster cast. This so-called 'functional' treatment is simple to apply, inexpensive, and virtually free of complications, and it allows work and sport can be resumed two to four times sooner than with the use of a plaster cast or surgery.10

The prognosis for an inversion injury is good, but the time required for recovery depends on the severity of the injury. Patients with a mild sprain are usually capable of resuming normal activities within 1-2 weeks.11 The average duration of absence from work for patients with a functionally treated rupture is 2.5 weeks, and 90% have resumed work by 6 weeks. Of those who engage in a sport, 60 to 90% have resumed their activity within 12 weeks and at the same level as prior to the injury. Although residual complaints such as pain, stiffness, swelling, and a feeling of instability or that the ankle is giving way again ('functional instability') occur in 20 to 40% of patients with a ligament rupture, these complaints do not appear to significantly affect the patient's ability to function.13

 

DIAGNOSTIC GUIDELINES

During the first consultation after the injury, the general practitioner should determine whether there is an indication for an x-ray.5 If a fracture is unlikely or has been ruled out, a physical examination should be carried out to distinguish between a sprain and a rupture. Distinguishing between a simple sprain and a rupture can be difficult during the initial consultation if there is a great deal of pain and swelling. If such is the case, the examination should be repeated 4-7 days later. Bruising also usually only becomes visible after this interval. In the interim, the patient should avoid movements which clearly aggravate the pain. Crutches can be used if desired.

 

Anamnesis  

Ask about:

 

Physical examination

Always comparing with the other ankle, note:

Palpate (and assess the degree of pain it causes):

 

Additional examinations and tests

X-rays should be ordered in case of any of the following:

 

Evaluation  

In all other cases, mildsprain should be diagnosed.

 

MANAGEMENT GUIDELINES

The guidelines below are applicable when a fracture has been ruled out and the general practitioner has diagnosed either a mild sprain or a rupture during the initial or subsequent consultation.

 

Information, advice, and non-medicinal treatment

 

There has not been sufficient investigation of the value of treating either mild sprains or ruptures with ice packs, compression bandages, elevation of the leg, or specific physiotherapy programmes with or without supervision by a therapist. Therefore neither positive nor negative recommendations can be given.15 Physical applications (ultrasound therapy, ultrashortwave diathermy, electrotherapy, and laser therapy) have been well studied, but have not been found to be effective and are therefore not recommended.15

 

Tape bandage  

The principle of treatment with a tape bandage is prevention of inversion, thereby protecting the lateral ligament. At the same time, dorsal and plantar flexion should remain possible, so that the foot can roll through normally during ambulation. The duration of treatment is six weeks.16

The tape should be applied with the foot at a ninety-degree angle to the lower leg, and in slight eversion. The bandage should be changed every two weeks, or earlier if it is too tight or too loose. The patient should be advised to keep the bandage dry in order to prevent the skin from becoming soft and infected. The following instructions should also be given:

Patients who engage in sports can generally resume training after six weeks. Advise them to start with cycling, swimming, or running/jogging on a flat surface. Competitive sports should only be resumed when normal training can be performed correctly.

 

Medicinal treatment

If desired, paracetamol can be prescribed for a few days (4 times daily, no more than 4,000 mg per day). NSAIDs are not recommended because of the risk of side effects and because research has shown that they do not have a beneficial effect on recovery from an inversion injury.17

 

 

Follow-up and prevention

Follow-ups are not necessary for a patient with a mild sprain. Instruct the patient to return if there is no improvement within 1-2 weeks, in which case the physical examination should be repeated.

A patient with a ruptured ligament who is treated with a tape bandage should be seen at two-week intervals for six-weeks. The general practitioner should ask about the symptoms, observe the patient's gait, and replace the bandage. A positive course is characterized by a rapid decrease in pain and swelling, recovery of a normal gait,and complete recovery of daily functioning (including work and sport).

After tape bandaging, patients who engage in sports with a high risk of inversion injury (such as football, basketball, outdoor hockey) should be advised to use an ankle brace for secondary prevention.18

 

Referral

If there is a fracture, refer the patient to an orthopaedic surgeon. Consider referral to a physiotherapist for training of coordination and muscle strength if marked limitations persist because of a feeling of instability, or the ankle repeatedly gives way, or there is muscle weakness, despite appropriate treatment and preventative measures.19 If treatment is insufficiently effective, consultation with, or referral to, an orthopaedic surgeon can be considered to discuss the possibility of secondary reconstruction of the capsular ligament complex.20

 


note 1     Back

Two other guidelines for the diagnosis and treatment of acute ankle injuries have been published recently in the Netherlands.1 2 The CBO consensus was drawn up by a workgroup of orthopaedic surgeons, radiologists, sport physicians, epidemiologists, physiotherapists, and general practitioners. Thus, to serve all professional groups there are now three guidelines which, by mutual agreement, are identical in terms of the main points.

  1. Anonymous. Consensus Diagnostiek en behandeling van het acute enkelletsel [Consensus on the diagnosis and treatment of acute ankle injuries]. CBO, Utrecht 1998.
  2. De Bie RA, Hendriks HJM, Lenssen AF, et al. KNGF-Richtlijn Acuut enkelletsel. [Royal Dutch physiotherapy Society guidelines on acute ankle injury]. Supplement to Ned Tijdschr Fysiotherapie 1998;108 (1).

note 2     Back

In the first version of this practice guideline, 'sprain' was used for a mild ligament injury and 'manifest ligament injury' was used for a more severe ligament injury.1 In this updated version the terms 'mild sprain' and 'rupture' have been chosen in keeping with the literature and the CBO consensus mentioned in the previous note. This distinction has important consequences for treatment and prognosis. In the first version of this guideline, 'eversion injury' was also discussed, but because its incidence is low and no specific treatment is needed, it is no longer included.

  1. Van den Bosch WJHM, Coumans RHM, Verkerk S, Van Weert H, Sips AJBI. NHG-Standaard enkeldistorsie.[NHG Standard 'Ankle sprain']. In: Rutten GEHM, Thomas S (eds). NHG-Standaarden voor de huisarts deel I [NHG Standards for the general practitioner part I]. Bunge, Utrecht 1993.

note 3     Back

In the Netherlands an estimated 600,000 people sustain ankle injuries each year. Roughly half of these people visit general practitioners or, on their own initiative, hospital casualty departments.1 At least half the injuries occur on playing fields.2 More than three-quarters of the ankle injuries are inversion injuries.

In diagnosis recording projects in Dutch general practice, 'ankle sprain' is coded separately. The Transition Project reports its incidence to be 11.1 per 1,000 patients per year, but does not indicate the severity of the injury nor the percentage of patients treated with a tape bandage.3 However, 85% of the cases are resolved in four weeks or less, which suggests that the course is usually positive. The Continuous Morbidity Registration found an incidence of 12.8 per 1,000 patients per year during the period 1993-1997.4 These figures indicate that each year approximately 200,000 patients consult general practitioners because of inversion injuries. For an 'average' practice of 2,350 patients, this means one new patient with this condition every two weeks.

The number of patients visiting hospital casualty departments with ankle injuries can be determined using the Privé Ongevallen Registratie Systeem (PORS) [Private Accidents Registration System] run by the Stichting Consument en Veiligheid [Dutch Consumer and Safety Association]. Since 1983 this system has recorded all private accident cases presented to the casualty departments of 14 representative hospitals and the information is then used to calculate figures for all Dutch hospitals. 'Private accidents' include all accidents except road traffic and occupational accidents and they represent 85% of all accidents. During the period 1990-1994, on average 70,000 patients per year were treated for inversion injuries.5 More than half of these patients were referred to specialists for further diagnosis and treatment. The remainder received a single treatment in the casualty department and/or were referred back to the general practitioner.

  1. Mulder S, Bloemhoff A, Harris S, et al. Ongevallen in Nederland, opnieuw gemeten [New figures on accidents in the Netherlands]. Stichting Consument en Veiligheid, Amsterdam 1995.
  2. Schmikli SL, Backx FJG, Bol E. Sportblessures nader uitgediept [Further insight into sporting injuries]. Bohn Stafleu Van Loghum, Houten/Diegem 1995.
  3. Okkes IM, Oskam SK, Lamberts H. Van klacht naar diagnose (boek met cd-rom) [From symptom to diagnosis (book with CD-ROM)]. Coutinho, Bussum 1998.
  4. CMR Nijmegen, diskette 1993-1997 [Nijmegen CMR 1993-1997 floppy disk]. University of Nijmegen, 1997.
  5. Anonymous. PORS registratie 1990-1994 [PORS registration 1990-1994]. Stichting Consument en Veiligheid, Amsterdam 1995.

note 4     Back

The exact proportion of fractures in patients who visit the general practitioner after an inversion injury is not known. Although the Transition Project reports a fracture of the tibia or fibula in 2% of the patients seeking help for 'ankle problems', it is not clear whether inversion injuries alone were involved. In addition, the proportion of foot fractures (particularly of the fifth metatarsal bone) is not given.1 The fracture rate in patients visiting hospital casualty departments is between 15 and 20%. Zeegers found fractures in 472 (15%) of 3,129 patients with inversion injuries, the majority of which involved the lateral malleolus or the fifth metatarsal bone.2 These included 54 fractures of the lateral malleolus below the tibiofibular syndesmosis (Weber type A) and 129 fractures of the shaft of the fifth metatarsal bone (Jones' fracture) or the base of this bone. Functional treatment of these fractures with a tape bandage is usually sufficient. In a study by Stiell et al. of 2,342 patients who visited the casualty department because of an ankle injury, 472 (20%) were found to have a fracture.3 Here too, at least three-quarters of the fractures involved the lateral malleolus or the fifth metatarsal bone. Eighteen percent of the fractures were avulsion fractures, for which functional treatment is also suitable.

  1. Lamberts H. Huisartsgeneeskundig handelen bij enkelklachten [Methods in general practice for ankle problems]. Huisarts Wet 1991;34:35-9.
  2. Zeegers AVCM. Het supinatieletsel van de enkel [Supination injury of the ankle] [thesis]. Utrecht University, Utrecht 1995.
  3. Stiell IG, McKnight RD, Greenberg GH, et al. Implementation of the Ottawa ankle rules. JAMA 1994;271:827-32.

note 5     Back

Studies carried out in Dutch general practices after publication of the first version of this practice guideline found that general practitioners request relatively few x-rays for inversion injuries, the rate ranging from 11 to 17% of cases.1 2 This is in keeping with a low prior probability of a fracture in general practice. A descriptive study in four casualty departments found that x-rays were performed in 46 to 88% of inversion injury cases.3

In a controlled clinical trial (n = 6,489), Stiell et al. studied a set of easy-to-use rules intended to limit the number of x-rays while minimizing the risk of missing a fracture.4 These 'Ottawa ankle rules' specify that an x-ray of the ankle or middle section of the foot should only be obtained in case of:5

The application of these rules by physicians with widely varying clinical experience in the eight casualty departments where the study took place led to a significant reduction in the number of x-rays, without any fractures being missed (sensitivity: 100%, specificity: 45%).4 The interobserver reliability of the various rules was good (kappa values: 0.66-0.83).6

The Ottawa ankle rules have not yet been similarly evaluated in general practice, but presumably the benefit of their application is mainly to be expected in outpatient clinics where too many x-rays are requested and there is a wish to reduce the number.3

Conclusion: the Ottawa ankle rules support the experience-based approach described in the first version of this guideline. Since they are the only well-validated criteria available, they have been included in this revised guideline.

  1. Lamberts H. Huisartsgeneeskundig handelen bij enkelklachten [Methods in general practice for ankle problems]. Huisarts Wet 1991;34:35-9.
  2. Grol R, Claessens A, Van der Velden J, Heerdink H. Kwaliteit van zorg bij enkeldistorsie: invoering van een standaard [Quality of care for ankle sprains; introduction of a standard]. Huisarts Wet 1991;34:30-4.
  3. Peters P, Wijkel D, Van der Meulen M, Adèr H. Diagnostiek en behandeling van enkelletsel [Diagnosis and treatment of ankle injuries]. Medisch Contact 1998;53:1098-101.
  4. Stiell IG, Wells G, Laupacis A, et al. Multicentre trial to introduce the Ottawa ankle rules for use of radiography in acute ankle injuries. BMJ 1995;311:594-7.
  5. Decision rules for the use of radiography in acute ankle injuries. JAMA 1993;269:1127-32.
  6. Stiell IG, McKnight RD, Greenberg GH, Nair RC, McDowell I, Wallace GJ. Interobserver agreement in the examination of acute ankle injury patients. Am J Emerg Med 1992;10:14-7.

note 6     Back

In three studies carried out in casualty departments of Dutch hospitals, the rate of ligament rupture in patients with inversion injuries was 8,1 16,2 and 18%3, respectively. In all cases the diagnosis was made using radiographic contrast imaging of the upper tarsal joint (arthrography) within five days after the injury, in patients selected on the basis of pain, swelling, and functional limitation. A positive arthrogram is highly predictive of the presence of a rupture.4

  1. Zeegers AVCM. Het supinatieletsel van de enkel [Supination injury of the ankle] [thesis]. Utrecht University, Utrecht 1995.
  2. Van Moppes FI, Van den Hoogenband CR. Diagnostic and therapeutic aspects of inversion trauma of the ankle joint [thesis]. Maastricht University, Maastricht 1982.
  3. Van Dijk CN. On diagnostic strategies in patients with severe ankle sprain [thesis]. Universiteit van Amsterdam, Amsterdam 1994.
  4. Van den Hoogenband CR, Van Moppes FI, Stapert JWJL, Greep JM. Clinical diagnosis, arthrography, stress examination and surgical findings after inversion trauma of the ankle. Arch Orthop Trauma Surg 1984;103:115-9.

note 7     Back

An experimental study revealed that in an inversion injury the anterior talofibular ligament takes the strain first and the fibulocalcaneal ligament and/or the posterior talofibular ligaments are only involved secondarily if greater force is applied.1 This has been confirmed in clinical research. During surgery in patients with an arthrographically identified rupture, Prins and Van der Ent both found an isolated rupture of the anterior talofibular ligament in half the patients and a combined rupture of the anterior talofibular ligament and the fibulocalcaneal ligament or the posterior talofibular ligament in the other half.2 3 Finally, a study in cadavers by Van Moppes and Van den Hoogenband revealed that these three ligaments should not be viewed as independent anatomical structures but rather as a continuum, which they called capsular reinforcementelements.4 

  1. Rasmussen O, Kromann-Andersen C. Experimental ankle injuries. Analysis of the traumatology of the ankle ligaments. Acta Orthop Scand 1983;54:356-62.
  2. Prins JG. Diagnosis and treatment of injury to the lateral ligament of the ankle. Acta Chir Scand 1978 (suppl.);486:3-149.
  3. Lateral ankle ligament injury [thesis]. Erasmus University, Rotterdam 1984.
  4. Van Moppes FI, Van den Hoogenband CR.Diagnostic and therapeutic aspects of inversion trauma of the ankle joint [thesis]. Maastricht University, Maastricht 1982.

 

note 8     Back

Kannus and Renström analysed twelve randomized studies of the efficacy of different types of treatment for patients with a rupture of one or more ligaments.1 On the basis of nine outcome variables, they concluded that there was no difference in outcome between an isolated and a combined rupture and that the results in the majority of patients ranged from good to excellent, regardless of whether treatment was by surgery, plaster cast, or tape bandage.

  1. Kannus P, Renström P. Treatment for acute tears of the lateral ligaments of the ankle. J Bone J Surg Am 1991;73:305-12.

note 9     Back

Van Dijk et al. examined the validity of the so-called delayed examination for diagnosing a rupture in 650 patients who visited the casualty department of a teaching hospital following an ankle injury, without referral by a general practitioner.1 The findings at surgery or the clinical course in patients who did not undergo surgery were used as the gold standard. After exclusion of those with fractures, contusions, and mild symptoms, 160 patients were eligible for arthrography within 48 hours after the injury and re-assessment after 4 to 7 days (average 5 days). The delayed examination consisted of the following three components:

Physical examination findings were considered to be positive for a rupture if there was pain upon palpation together with visible bruising or a positive anterior drawer test. Neither the patient nor the physician was aware of the result of the arthrogram at the time of the delayed examination. One hundred and thirty-five patients had a positive arthrogram and/or positive delayed examination findings, and underwent surgery. During surgery the diagnosis of 'rupture' was confirmed in 122 of the 650 patients, giving a rupture rate of 19%in the entire study group.

The diagnosis of 'rupture' was correctly predicted in 117 (95%) of the patients on the basis of the postponed examination. The sensitivity was 95% and the specificity was 77%. A rupture was unlikely in the absence of pain upon palpation or if the anterior drawer test was negative in combination with the absence of discolouration due to bruising. The inter-observer reliability for the different components of the postponed examination was found to be reasonable to excellent (kappa values: 0.5-1.0). It should be noted that this study was carried out in a hospital setting with a selected population. The predictive value of a positive delayed examination will be lower in a general practitioner's patient population due to the almost certainly lower incidence of serious injuries such as ruptures. This may lead to 'overtreatment' of patients who simply have a mild sprain. However, in view of the nature of the treatment (tape bandage) and the fact that the patient would probably have made a rapid recovery by the time of the follow-up, this objection is only relative. Furthermore, the current conservative approach for all inversion injuries means that it might become more common for patients to consult the general practitioner first.

Conclusion: this approach, which was developed in a hospital setting, led to revision of the recommendations given in the first version of this practice guideline and hence inclusion of the principle of the delayed examination in this updated version. Translation of this approach to daily general practice means that after the first examination only patients with a great deal of pain, swelling, and functional limitation need to return 4-7 days later for reassessment. The diagnosis of 'rupture' is then likely if the following are found:

In all other cases, the diagnosis should be 'mild sprain'. 

  1. Van Dijk CN, Lim LSL, Bossuyt PMM, Marti RK. Physical examination is sufficient for the diagnosis of sprained ankles. J Bone Joint Surg Br 1996;78:958-62.

 

note 10     Back

The study carried out by Van Moppes and Van den Hoogenband has been the key to the management of ankle injuries in the Netherlands.1 In a randomized study they compared three interventions in patients with a rupture: tape bandage for 6 weeks using method of Coumans, surgery followed by plaster cast for 5 weeks, and plaster cast for 6 weeks. Work could be resumed after 2.5, 9.7, and 6.8 weeks, respectively. After 12 weeks, 80% of the patients in the tape group who engaged in a sport had resumed their sport activity, while only 40% of those in the other treatment groups had done so. After one year there were no clinically relevant differences among the three groups. After analysing the results of 12 randomized studies (including the above), Kannus et al. reached the following conclusion: 'It is not difficult to select functional treatment as the treatment of choice for acute complete tears of the lateral ligament of the ankle'.2 Ogilvie-Harris reached a similar conclusion after examining 37 studies which compared surgery, plaster cast, and/or functional treatment.3 The recently-published CBO consensus agreed with this conclusion on the basis of its own meta-analysis of the outcomes of studies of superior quality.4

  1. Van Moppes FI, Van den Hoogenband CR. Diagnostic and therapeutic aspects of inversion trauma of the ankle joint [thesis]. Maastricht University, Maastricht 1982.
  2. Kannus P, Renström P. Treatment for acute tears of the lateral ligament of the ankle. J Bone J Surg 1991;73:305-12.
  3. Ogilvie-Harris DJ, Gilbart M. Treatment modalities for soft tissue injuries of the ankle: a critical review. Clin J Sport Med 1995;5:175-86.
  4. Anonymous. Consensus Diagnostiek en behandeling van het acute enkelletsel [Consensus on the diagnostic procedures and treatment of acute ankle injuries]. CBO, Utrecht 1998.

note 11     Back

There has been very little investigation of the course of mild sprains and any residual complaints, presumably because the management of these problems has never been the subject of significant discussion. Jackson et al. investigated the course of mild sprains in servicemen and found complete recovery of daily activities within 1-2 weeks.1 Five years after diagnosis, Zeegers interviewed every tenth patient in a group of 2,728 in whom mild sprain was diagnosed on clinical grounds.2 Fifty-two percent (n = 164) of this sample group responded. Although 10 to 40% of those interviewed reported having pain, stiffness, a feeling of instability, and problems with the ankle giving way, these difficulties led to few or no limitations in daily life. Of those who had engaged in a sport (n = 113), only 8% reported having had to give up the sport because of ankle-related problems.

  1. Jackson DW. Ashley RL, Powell JW. Ankle sprains in young athletes. Relation of severity and disability. Clin Orthop 1974;101:201-15.
  2. Zeegers AVCM. Het supinatieletsel van de enkel [Supination injury of the ankle] [thesis]. Utrecht University, Utrecht 1995.

note 12     Back

The term 'functional instability' is found frequently in the literature. It is often used in efficacy studies as an outcome variable, but various definitions are employed. It is a subjective problem in that the patient, on being asked, indicates that he cannot always rely on the ankle and claims to be afraid that the ankle will once again give way. However, this feeling of instability can be present without the ankle ever actually having given way or without the patient feeling limited in his activities. Freeman was the first to develop the hypothesis that the problem is caused by the fact that the proprioceptive receptors in or surrounding the ankle ligament become damaged or lost during the injury.1 Several studies have found no association between functional instability and objectively-measured mechanical instability.2 3 It is assumed that proprioception and loss of muscle strength play a role in the development of functional instability.4

  1. Freeman MAR, Dean MRE, Hanham IWF. The etiology and prevention of functional instability of the foot. J Bone Joint Surg 1965;47:678-85.
  2. Prins JG. Diagnosis and treatment of injury to the lateral ligament of the ankle. Acta Chir Scand 1978 (suppl.);486:3-149.
  3. Van der Ent FWC. Lateral ankle ligament injury [thesis]. Erasmus University, Rotterdam 1984.
  4. Tropp H, Askling C, Gillquis J. Prevention of ankle sprains. Am J Sports Med 1985;13:259-62.

note 13     Back

The prognosis for patients with a treated rupture is good, as shown by the studies of van Van Moppes and Van den Hoogenband (see note 10) and Zeegers, among others. Zeegers compared four forms of functional treatment in patients with an arthrographically identified rupture: tape bandage using the method of Coumans, an ankle brace, a stabilizing shoe, and an elastic stocking.1 This study found that the elastic stocking (the most 'minimal' form of treatment) led to a slightly longer absence from work (23 days compared with 16 days for tape bandage), but that there were no differences among the four forms of treatment in the other usual endpoints. After one year, 80% of the patients in all groups were free of symptoms.

  1. Zeegers AVCM. Het supinatieletsel van de enkel [Supination injury of the ankle] [thesis]. Utrecht University, Utrecht 1995.

 

note 14     Back

Performing the anterior drawer test:1

Interpretation: the test is positive if the foot moves 1 cm or more ventrally relative to the lower leg and compared with the healthy limb.

  1. Van Dijk CN, Mol BWJ, Lim LSL, Marti RK, Bossuyt PMM. Diagnosis of ligament rupture of the ankle joint. Acta Orthop Scand 1996;67:566-70.

note 15     Back

There has been very little good quality research about the effect of rest, ice, compression, and elevation (known as the 'RICE' principle), although these measures are frequently recommended in practice and in the literature for use in the acute or subacute phase. Studies of this principle have generally been of moderate or poor methodological quality and the conclusions are contradictory. Both the guidelines quoted in note 1 and the review by Ogilvie-Harris1 include overviews of these studies. The conclusion is that there is as yet insufficient scientific verification of the RICE principle.

Several reviews of studies of the efficacy of physical techniques have been published recently. Van der Windt et al. found evidence that the use of ultrasound is ineffective.2 De Bie et al. examined studies of the effect of ultrasound, electrotherapy, laser therapy, and ultrashortwave diathermy, concluded that these methods are ineffective, and advised that they should not be used.3

There have been very few randomized studies of the effect of specific home exercises or physiotherapy under the supervision of a therapist and, as far is known, these have not yet been carried out in patients with ligament ruptures. In a randomized study, Oostendorp investigated the effect of an exercise programme (home exercises as well as exercising three times a week under the guidance of a therapist, for 6 weeks) in 24 athleteswith a sprained ankle.4 Those with ligament ruptures were excluded. Efficacy was measured under blinded conditions after 6, 12, and 24 weeks. The outcome variables were pain, functional instability (defined as 'fear of the ankle giving way'), and functional recovery (resuming work and sport). No data on recurrences were presented. Results: with the exception of functional instability (p = 0.05), there were no significant differences at 24 weeks. Wester et al. studied the effect of a 12-week daily training programme on a wobble board in 61 athletes with an inversion injury and a negative anterior drawer test at 4-7 days after the injury.5 After an average follow-up of 230 days, the participants were asked about pain when engaged in the sport, recurring inversion injuries, and functional instability. Thirteen (21%) of the patients dropped out of the study for various reasons. There was no difference between the treatment and control groups in the degree of pain experienced while engaged in a sport. However, in the treatment group there were significantly fewer relapses (6 versus 13) and episodes of functional instability (0 versus 6). No information was given about the length of time until sport was resumed, the need to discontinue a sporting activity because of ankle problems, or perceived limitations. Conclusion: the latter two studies suggest that beneficial effects on functional instability and/or the occurrence of relapses might be expected from a specific training programme for patients who engage in high-risk sports. Further higher quality research involving greater numbers of patients, including those with ruptures, must be carried out before clear guidelines can be drawn up on this subject.

  1. Ogilvie-Harris DJ, Gilbart M. Treatment modalities for soft tissue injuries of the ankle: a critical review. Clin J Sport Med 1995;5:175-86.
  2. Van der Windt DAWM, Van der Heijden GJMG, Van den Berg SGM, Ter Riet G, De Winter AF, Bouter LM. Effectiviteit van ultrageluidbehandeling voor aandoeningen van het bewegingsapparaat: een systematische review [Efficacy of ultrasound treatment for conditions involving the motor apparatus: a systematic review]. Ned Tijdschr Fysiother 1999;109:14-23.
  3. De Bie RA, Hendriks HJM, Lenssen AF, et al. KNGF-Richtlijn Acuut enkelletsel [Royal Dutch Physiotherapy Society guideline on acute ankle injuries]. Supplement to Ned Tijdschr Fysiotherapie 1998;108 (1).
  4. Oostendorp RAB. Functionele instabiliteit na het inversietrauma van enkel en voet: een effectonderzoek pleisterbandage versus pleisterbandage gecombineerd met fysiotherapie [Functional instability following inversion injury to the ankle and foot: an efficacy study of tape bandage versus tape bandage combined with physiotherapy]. Geneeskunde en Sport 1987;20:45-54.
  5. Wester JU, Jespersen SM, Nielsen KD, Neumann L. Wobble board training after partial sprains of the lateral ligaments of the ankle: a prospective randomised study. J Orthop Sports Phys Ther 1996;23:332-6.

note 16     Back

A tape bandage is intended to support the ankle joint. Different materials can be used alone or in combination. The bandage material must have an adhesive layer which allows it to adhere to the skin and to itself. Since the direct stabilizing effect of a bandage lasts no longer than about half an hour, the positive effect is presumed to occur primarily through traction on the skin which stimulates muscular activity.1

There are various bandaging techniques, such as those of Coumans, Snellenberg, and Van Wingerden. The technique of applying the bandage does not vary greatly among them. Comparative studies using the Coumans bandage have been carried out in the Netherlands.1 2 This technique requires practice and is fairly labour intensive.2 It is not known how extensively this technique is still being used. There are indications that it can probably be done more simply. In a randomized study in 243 patients with an arthrographically identified rupture, Zeegers compared four forms of functional treatment: a tape bandage according to Coumans, an ankle brace, a stabilizing shoe, and an elastic stocking.1 Use of the elastic stocking (the most 'minimal' form of treatment) led to slightly longer absence from work (23 days compared with 16 days for the tape bandage), but there were no differences among the four forms of treatment in terms of the other usual endpoints. After one year, at least 80% of the patients in all groups were free of symptoms. Although the small number of patients per treatment group makes it difficult to reach a definitive conclusion, it is worth noting that in this study the simple elastic stocking was more or less equivalent to the other materials. Further research (in general practice!) is required to determine which (preferably general practitioner-friendly and patient-friendly) material will ultimately be the first choice.

  1. Zeegers AVCM. Het supinatieletsel van de enkel [Supination injury of the ankle] [thesis]. Utrecht University, Utrecht 1995.
  2. Van Moppes FI, Van den Hoogenband CR. Diagnostic and therapeutic aspects of inversion trauma of the ankle joint [thesis].  Maastricht University, Maastricht 1982.

note 17     Back

Overviews of randomized controlled trials on the effect of analgesics on the course of ankle injuries (both mild/moderate sprains and ruptures) can be found in the review by Ogilvie-Harris and in the CBO Consensus.1 2 In most studies NSAIDs were compared with placebo or with each other. No studies were found in which paracetamol was compared with an NSAID or placebo. The outcome variables were pain, swelling, functional and activity recovery, and side effects.

Results: although pain usually subsided slightly more rapidly in the treatment groups than in the placebo groups, there were no differences in overall recovery.

Conclusion: NSAIDs have no clinically relevant effect on recovery from ankle injuries. If pain relief is desired, appropriately-dosed paracetamol should be the first choice, partly because of the difference in side-effects.

  1. Ogilvie-Harris DJ, Gilbart M. Treatment modalities for soft tissue injuries of the ankle: a critical review. Clin J Sport Med 1995;5:175-86.
  2. Anonymous. Consensus Diagnostiek en behandeling van het acute enkelletsel [Consensus on the diagnostic procedures and treatment of acute ankle injuries]. CBO, Utrecht 1998.

note 18     Back

Quinn et al. systematically reviewed randomized controlled studies of the effect of primary and secondary prevention of inversion injuries to the ankle.1 Five of the eleven identified studies met the review's inclusion criteria. The studies were carried out in young, active (mainly male) persons who participated in high-risk sports, such as football, basketball, and parachute jumping. The preventive measures studied were a high basketball shoe, an ankle brace worn outside the shoe, a semi-rigid ankle brace, and training on a wobble board. Results: there was a significant reduction in the number of ligament injuries as the result of wearing preventative braces by persons participating in sports following a ligament injury (odds ratio (OR) 0.31; 95% confidence interval (CI) 0.19-0.49). The reduction of risk in persons engaging in a sport and having no history of ligament injury (secondary prevention) was not significant (OR 0.70; 95% CI 0.47-1.03). The wobble board training was only investigated in the context of secondary prevention, but did lead to a significant reduction in ankle ligament injuries (OR 0.30; 95% CI 0.15-0.60). However, given the design of the study, the authors believe further research to be necessary before advocating general use of this technique.2

Conclusion: the use of preventive braces for secondary prevention is beneficial in persons engaged in a sport with a high initial risk of injury to the ankle ligaments.

  1. Quinn K, Parker P, De Bie RA, Rowe B, Handoll H. The prevention of ankle ligament injuries (Cochrane Review). In: The Cochrane Library, Issue 1, 1999. Oxford: Update software.
  2. Tropp H, Askling C, Gillquist J. Prevention of ankle sprains. Am J Sports Med 1985;13:259-62.

note 19     Back

The considerations behind this pragmatic advice are as follows. Numerous efficacy studies have found that the prognosis for ankle ligament injury is good to excellent and that a functional approach to ligament rupture (immobilizing by a tape bandage combined with a few simple recommendations) is the treatment of choice. In addition, secondary prevention provided by wearing a brace will benefit patients who engage in sports with a high risk of ankle injuries. Good results will be achieved with this approach in the majority of patients.

There have been no good efficacy studies of patients in whom problems leading to limitations in daily life, including sport, persist despite these measures. Given the results of studies of the effect of special training, such as those by Wester et al. (see note 15) and Tropp et al. (see note 18), referral of patients in this specific group may be considered. Further research is required to determine which interventions will be effective for which type of problem.

 

note 20     Back

In 1980 Duquennoy et al. introduced a surgical method which used tissue available at the site of the injury to reconstruct the anterior talofibular ligament.1 This technique (or a modified version) is currently one of the most commonly used methods for secondary treatment of ankle instability. Castelein et al. described results in 32 patients with severe instability problems (recurrent sprains with pain and swelling) in whom conservative measures had failed.2 Treatment consisted of Duquennoy's reconstructive surgery followed by 6 weeks in a plaster cast and exercises under the supervision of a physiotherapist. The follow-up period was not mentioned. Results: 22 patients (69%) were completely free of problems. Instability, determined objectively using stress x-rays, decreased on average by 63% (talar tilt) and 40% (drawer test). No details were given about complications.

  1. Duquennoy A, Létendard J, Loock Ph. Remise en tension ligamentaire externe dans les instabilités chroniques de la cheville. A propos de 22 casus [Restoration of external ligament tension in the case of chronic ankle instability. A review of 22 cases]. Rev Chir Orthop 1980;66:311-6.
  2. Castelein RM, Fiévez AWFM, Tissink J. Een eenvoudige operatiemethode ter behandeling van het chronisch instabiele enkelgewricht [A simple surgical method for the treatment of chronic ankle instability]. Ned Tijdschr Geneeskd 1986;130:494-7.
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